Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 3/20 | 0.66 |
| ▸ | PRKCI | P41743 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7850695 | 0.84 | PRKCZ (0.66) | PRKCZPRKCIMAPTHPGDALDH1A1 | |
| SCHEMBL3386676 | 0.80 | PRKCZ (1.00) | PRKCZPRKCIMAPTHPGDALDH1A1 | |
| SCHEMBL3383816 | 0.77 | MAPT (0.76) | PRKCZMAPTHPGDALDH1A1TDP1 | |
| SCHEMBL21247139 | 0.77 | MAPT (0.76) | PRKCZMAPTHPGDALDH1A1TDP1 | |
| SCHEMBL3935628 | 0.77 | MAPT (0.76) | MAPTHPGDALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL18926179 | 0.77 | MAPT (0.76) | PRKCZPRKCIMAPTHPGDALDH1A1 | |
| SCHEMBL22117121 | 0.77 | PRKCI (0.56) | PRKCZPRKCIMAPTHPGDALDH1A1 | |
| SCHEMBL2369163 | 0.76 | MAPT (1.00) | MAPTHPGDALDH1A1TDP1SMN1; SMN2 | |
| SCHEMBL10018127 | 0.74 | PRKCI (0.53) | PRKCZPRKCIMAPTHPGDALDH1A1 | |
| SCHEMBL10049626 | 0.74 | MAPT (0.58) | PRKCZPRKCIMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |