Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 9/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.68 |
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | PRKCI | P41743 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | MPI | P34949 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25487711 | 0.89 | PRKCZ (0.73) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL8289654 | 0.85 | PRKCZ (1.00) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL690278 | 0.85 | PRKCZ (0.84) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL1554707 | 0.85 | PRKCZ (0.75) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL8290826 | 0.85 | PRKCZ (0.79) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL1554182 | 0.84 | PRKCZ (0.82) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL8290363 | 0.84 | PRKCZ (0.82) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL14123517 | 0.84 | PRKCZ (0.73) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL8288714 | 0.84 | PRKCZ (0.81) | PRKCZALDH1A1HSD17B10HPGDPRKCI | |
| SCHEMBL8290711 | 0.84 | PRKCZ (0.69) | PRKCZALDH1A1HSD17B10HPGDPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |