Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 7/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3184865 | 0.84 | KDR (0.47) | KDRFGFR3FLT3ALK | |
| SCHEMBL3385534 | 0.84 | KDR (0.50) | KDRFGFR3FLT3AURKARAF1 | |
| SCHEMBL3385275 | 0.82 | KDR (0.51) | KDRFGFR3FLT3AURKAALK | |
| SCHEMBL3177731 | 0.81 | KDR (0.43) | KDRFGFR3FLT3AURKARAF1 | |
| SCHEMBL3183874 | 0.81 | KDR (0.52) | KDRFGFR3FLT3AURKAALK | |
| SCHEMBL3193787 | 0.81 | KDR (0.62) | KDRFGFR3 | |
| SCHEMBL3382976 | 0.80 | KDR (0.43) | KDRFGFR3FLT3AURKARAF1 | |
| SCHEMBL3382628 | 0.77 | KDR (0.56) | KDRFGFR3RAF1 | |
| SCHEMBL13336658 | 0.75 | KDR (0.69) | KDRFGFR3 | |
| SCHEMBL3197804 | 0.74 | KDR (0.55) | KDRFGFR3HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |