Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.43 |
| ▸ | FLT3 | P36888 | 8/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385873 | 0.89 | FLT3 (0.49) | KDRFLT3RETCSF1RRAF1 | |
| SCHEMBL3385534 | 0.85 | KDR (0.50) | KDRFLT3ALKAURKARET | |
| SCHEMBL3385275 | 0.83 | KDR (0.51) | KDRFLT3ALKAURKARET | |
| SCHEMBL3177731 | 0.83 | KDR (0.43) | KDRFLT3ALKAURKARET | |
| SCHEMBL3184865 | 0.83 | KDR (0.47) | KDRFLT3ALKFGFR3 | |
| SCHEMBL3183874 | 0.81 | KDR (0.52) | KDRFLT3ALKAURKAFGFR3 | |
| SCHEMBL3385316 | 0.80 | KDR (0.48) | KDRFLT3ALKAURKAFGFR3 | |
| SCHEMBL3383422 | 0.79 | FGFR3 (0.53) | KDRFGFR3 | |
| SCHEMBL3382628 | 0.77 | KDR (0.56) | KDRFGFR3RAF1 | |
| SCHEMBL3383912 | 0.74 | KDR (0.51) | KDRFGFR3RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |