Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368361 | 0.93 | TNF (0.56) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2369471 | 0.89 | ALDH1A1 (0.47) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2368394 | 0.87 | TNF (0.51) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5818525 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2368514 | 0.85 | CLK4 (0.44) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2369234 | 0.85 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL3386697 | 0.85 | TNF (0.48) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2368683 | 0.83 | TNF (0.56) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3386735 | 0.82 | TNF (0.59) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2368488 | 0.80 | TNF (0.59) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |