Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729244 | 0.84 | NPSR1 (0.76) | MEN1KMT2AMAPTALDH1A1NPSR1 | |
| SCHEMBL27753752 | 0.83 | MEN1 (0.48) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL8998155 | 0.83 | PLA2G2A (0.55) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL290852 | 0.81 | GAA (0.79) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL805706 | 0.81 | S1PR3 (0.60) | MEN1KMT2APPARG | |
| SCHEMBL10778316 | 0.80 | MAPT (0.59) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL3388126 | 0.80 | PLA2G2A (0.68) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL612585 | 0.79 | POLB (0.62) | MEN1KMT2AMAPTGAAPKM | |
| SCHEMBL9056683 | 0.79 | NPSR1 (0.64) | MEN1KMT2AMAPTNPSR1LMNA | |
| SCHEMBL10840421 | 0.79 | PLA2G2A (0.62) | MEN1KMT2AMAPTGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771424-B1 | NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-15 | — | — | EP | claimed |
| US-7423053-B2 | 4-Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | claimed |
| EP-1771424-A1 | NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-11 | — | — | EP | claimed |
| WO-2006005508-A1 | NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-01-19 | — | — | WO | claimed |
| US-20060014958-A1 | 4-Aminothiazole derivatives | CHEN LI | 2006-01-19 | — | — | US | claimed |
| EP-1771424-B1 | NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-15 | — | — | EP | disclosed |
| US-7737173-B2 | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity | ALLERGAN, INC. (US) | 2010-06-15 | — | — | US | disclosed |
| EP-1984334-A2 | INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY | Allergan, Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| US-7423053-B2 | 4-Aminothiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-09-09 | — | — | US | disclosed |
| WO-2007095561-A2 | INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 2007-08-23 | — | — | WO | disclosed |
| US-20070191313-A1 | INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY | ALLERGAN, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20060014958-A1 | 4-Aminothiazole derivatives | CHEN LI | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014958-A1 | 4-Aminothiazole derivatives | CDK4, CDK2, CCNI | MEN1 3153/4885KMT2A 509/4885MAPT 2328/4885 |
| US-20070191313-A1 | INDOLE-3-CARBOXYLIC ACID AMIDE, ESTER, THIOAMIDE AND THIOL ESTER COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ANTAGONIST BIOLOGICAL ACTIVITY | S1PR3, S1PR1, S1PR2 | MEN1 4527/4885KMT2A 3030/4885MAPT 4447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.