Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 7/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3381118 | 0.90 | NPC1 (0.54) | KDRFGFR3RAF1FLT3NPC1 | |
| SCHEMBL3383912 | 0.87 | KDR (0.51) | KDRFGFR3RAF1MAPK14MAPK13 | |
| SCHEMBL3386414 | 0.87 | RAF1 (0.58) | KDRFGFR3RAF1FLT3RIPK2 | |
| SCHEMBL3383110 | 0.84 | RET (0.48) | KDRFGFR3FLT3CSF1R | |
| SCHEMBL3189872 | 0.84 | KDR (0.50) | KDRFGFR3RAF1FLT3RIPK2 | |
| SCHEMBL3384443 | 0.83 | MAPT (0.55) | KDRFGFR3RAF1FLT3RIPK2 | |
| Trifluoroacetic Acid SCHEMBL3385303 | 0.83 | FGFR3 (0.48) | KDRFGFR3RAF1FLT3RIPK2 | |
| SCHEMBL3385534 | 0.82 | KDR (0.50) | KDRFGFR3RAF1FLT3RIPK2 | |
| SCHEMBL3383229 | 0.81 | NPC1 (0.52) | RAF1FLT3NPC1RAB9AMAPK14 | |
| SCHEMBL3198885 | 0.81 | NPC1 (0.53) | RAF1FLT3NPC1RAB9AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |