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Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL3385303

CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cnc4cc(-c5ccncc5)ccn34)c(F)c2)no1.O=C(O)C(F)(F)F

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ FGFR3 P22607 2/20 0.48
▸ KDR P35968 1/20 0.48
▸ RAF1 P04049 6/20 0.47
▸ FLT3 P36888 10/20 0.46
▸ RIPK2 O43353 1/20 0.45
▸ MAPK14 Q16539 1/20 0.45
▸ MAPK3 P27361 2/20 0.42
▸ MEN1 O00255 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3386414 0.85 RAF1 (0.58) FGFR3KDRRAF1FLT3RIPK2
SCHEMBL3385983 0.83 KDR (0.47) FGFR3KDRRAF1FLT3RIPK2
SCHEMBL3385308 0.81 KDR (0.41) FGFR3KDRRAF1RIPK2
SCHEMBL3381118 0.81 NPC1 (0.54) FGFR3KDRRAF1FLT3MAPK14
SCHEMBL3189872 0.79 KDR (0.50) FGFR3KDRRAF1FLT3RIPK2
SCHEMBL3383912 0.77 KDR (0.51) FGFR3KDRRAF1MAPK14
SCHEMBL3384443 0.77 MAPT (0.55) FGFR3KDRRAF1FLT3RIPK2
SCHEMBL3385534 0.76 KDR (0.50) FGFR3KDRRAF1FLT3RIPK2
SCHEMBL3383110 0.75 RET (0.48) FGFR3KDRFLT3
SCHEMBL3383229 0.75 NPC1 (0.52) RAF1FLT3MAPK14NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904494-B1 IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS LILLY CO ELI (US) 2010-12-01 — — EP disclosed