Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387655 | 0.90 | PAK1 (0.53) | PTGDR2GRM4FLT3CDK2CCNA2 | |
| SCHEMBL3386078 | 0.85 | KDM4E (0.46) | FLT3FGFR1FGFR2FGFR3JAK2 | |
| SCHEMBL3385649 | 0.83 | NPC1 (0.50) | WNT1DYRK1A | |
| SCHEMBL3383259 | 0.79 | MAPT (0.57) | ITKGSK3B | |
| SCHEMBL3386831 | 0.79 | NPC1 (0.54) | FLT3PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3385551 | 0.77 | SGK1 (0.47) | FLT3CDK2CCNA2CCNA1PRKAG1 | |
| SCHEMBL3386038 | 0.75 | DYRK1A (0.48) | FLT3CDK2CCNA2CCNA1PRKAG1 | |
| SCHEMBL3380466 | 0.75 | PAK1 (0.47) | PRKAG1PRKAA1PRKAB1JAK2JAK1 | |
| SCHEMBL3386591 | 0.75 | KDR (0.50) | FLT3PRKAG1PRKAA1PRKAB1JAK3 | |
| SCHEMBL3384011 | 0.74 | HDAC1 (0.51) | PTGDR2FLT3CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |