Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | ANPEP | P15144 | 2/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386548 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP3A4EPHX1CTSSCTSK | |
| SCHEMBL3386550 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP3A4EPHX1CTSSCTSK | |
| SCHEMBL3383789 | 0.81 | CTSS (0.40) | CYP1A2CYP3A4CTSSCTSKBCHE | |
| SCHEMBL13004796 | 0.80 | EPHX1 (0.37) | CYP1A2CYP3A4EPHX1CTSSCTSK | |
| SCHEMBL3627651 | 0.79 | ACACB (0.40) | BCHE | |
| SCHEMBL3627659 | 0.79 | ACACB (0.40) | BCHE | |
| SCHEMBL3627656 | 0.79 | ACACB (0.40) | BCHE | |
| SCHEMBL83288 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP3A4CA12CA1CA2 | |
| SCHEMBL81032 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP3A4CA12CA1CA2 | |
| SCHEMBL81030 | 0.79 | CYP1A2 (0.51) | CYP1A2CYP3A4CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8828974-B2 | Substituted propane phosphinic acid derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2014-09-09 | — | — | US | disclosed |
| US-20120208784-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | AVENTIS PHARMACEUTICALS INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8183231-B2 | Substituted propane phosphinic acid derivatives | AVENTIS PHARMACEUTICALS INC. (US) | 2012-05-22 | — | — | US | disclosed |
| EP-1765850-B1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | AVENTIS PHARMA INC (US) | 2010-12-01 | — | — | EP | disclosed |
| US-7687540-B2 | Substituted propane phosphinic acid esters | AVENTIS PHARMACEUTICALS INC. (US) | 2010-03-30 | — | — | US | disclosed |
| EP-1851234-B1 | SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS | AVENTIS PHARMA INC (US) | 2009-01-07 | — | — | EP | disclosed |
| US-20070270385-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS | AVENTIS PHARMACEUTICALS INC. (US) | 2007-11-22 | — | — | US | disclosed |
| EP-1851234-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS | Aventis Pharmaceuticals, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| EP-1765850-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | Aventis Pharmaceuticals, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20070060502-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | AVENTIS PHARMACEUTICALS INC. (US) | 2007-03-15 | — | — | US | disclosed |
| WO-2006086734-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| WO-2005118618-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270385-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID ESTERS | PHOSPHO1, PTEN, GRIA1 | CYP1A2 3382/4885CYP3A4 4138/4885EPHX1 618/4885 |
| US-20070060502-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | PHOSPHO1, PTEN, PLCB1 | CYP1A2 3286/4885CYP3A4 4499/4885EPHX1 1024/4885 |
| US-20120208784-A1 | SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES | PHOSPHO1, PTEN, PLCB1 | CYP1A2 3286/4885CYP3A4 4499/4885EPHX1 1024/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.