Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | PARP1 | P09874 | 5/20 | 0.64 |
| ▸ | AR | P10275 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19748763 | 0.84 | LMNA (0.67) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL3386671 | 0.84 | PARP1 (0.72) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL29655067 | 0.84 | LMNA (0.67) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL19748315 | 0.84 | LMNA (0.56) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL14607227 | 0.82 | AR (0.60) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL29483969 | 0.82 | PARP1 (0.72) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL28729869 | 0.82 | PARP1 (0.72) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL3386656 | 0.81 | CYP3A4 (0.80) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL19748213 | 0.81 | LMNA (0.58) | LMNAPARP1ARCYP3A4CYP2C9 | |
| SCHEMBL12955341 | 0.80 | AR (0.77) | LMNAPARP1ARCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9803180-B2 | S-adenosylmethionine (SAM) synthase variants for the synthesis of artificial cofactors | Leibniz-Institut für Pflanzenbiochemie Stiftung des öffentlichen Rechts (DE) | 2017-10-31 | — | — | US | disclosed |
| US-20170240870-A9 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | Leibniz-Institut für Pflanzenbiochemie Stiftung des öffentlichen Rechts (DE) | 2017-08-24 | — | — | US | disclosed |
| EP-3066197-B1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | LEIBNIZ-INSTITUT FÜR PFLANZENBIOCHEMIE STIFTUNG DES OFFENTLICHEN RECHTS (DE) | 2017-08-16 | — | — | EP | disclosed |
| US-20160264946-A1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | LEIBNIZ-INSTITUT FÜR PFLANZEN-BIOCHEMIE STIFTUNG DES ÖFFENTLICHEN RECHTS (DE) | 2016-09-15 | — | — | US | disclosed |
| EP-3066197-A1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | Leibniz-Institut Für Pflanzenbiochemie Stiftung Des Offentlichen Rechts (DE) | 2016-09-14 | — | — | EP | disclosed |
| WO-2015067331-A1 | S-ADENOSYLMETHIONINE (SAM) SYNTHASE VARIANTS FOR THE SYNTHESIS OF ARTIFICIAL COFACTORS | Leibniz-Institut für Pflanzenbiochemie Stiftung des öffentlichen Rechts (DE) | 2015-05-14 | — | — | WO | disclosed |
| EP-1725668-B1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2010-12-15 | — | — | EP | disclosed |
| EP-1501822-B1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARM LTD (GB) | 2010-12-15 | — | — | EP | disclosed |
| EP-1501822-B1 | PHTHALAZINONE DERIVATIVES | KUDOS PHARM LTD (GB) | 2010-12-15 | — | — | EP | disclosed |
| US-20090155911-A1 | Genetically modified plants and their applications in phytoremediation | COMMISSIARIAT A L'ENERGIE ATOMIQUE (FR) | 2009-06-18 | — | — | US | disclosed |
| US-7196085-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| US-7196085-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| US-7196085-B2 | Phthalazinone derivatives | KUDOS PHARMACEUTICALS LIMITED (GB) | 2007-03-27 | — | — | US | disclosed |
| EP-1725668-A1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2006-11-29 | — | — | EP | disclosed |
| WO-2005093078-A1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2005-10-06 | — | — | WO | disclosed |
| WO-2005090583-A1 | GENETICALLY MODIFIED PLANTS AND THEIR APPLICATIONS IN PHYTOREMEDIATION. | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 2005-09-29 | — | — | WO | disclosed |
| US-20040023968-A1 | Phthalazinone derivatives, and their use as pharmaceuticals. In particular, the present as enzyme inhibitors | KUDOS PHARMACEUTICALS LIMITED (GB) | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023968-A1 | Phthalazinone derivatives, and their use as pharmaceuticals. In particular, the present as enzyme inhibitors | PARP1, PARP2, PARP15 | LMNA 233/4885PARP1 1/4885AR 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.