Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.67 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PRKAG1 | P54619 | 10/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 10/20 | 0.52 |
| ▸ | PRKAB2 | O43741 | 9/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 9/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 9/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 9/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380509 | 0.87 | FGFR1 (0.58) | PDPK1JAK2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3387378 | 0.84 | PDPK1 (0.60) | PDPK1AAK1JAK2PRKAG1PRKAA1 | |
| SCHEMBL2919160 | 0.84 | PRKAG1 (0.48) | PRKAG1PRKAA1PRKAB1PRKAB2PRKAA2 | |
| SCHEMBL3385023 | 0.81 | KDM4E (0.60) | PDPK1AAK1JAK2FGFR1FGFR2 | |
| SCHEMBL12907253 | 0.81 | PDPK1 (1.00) | PDPK1AAK1JAK2AURKAFGFR1 | |
| SCHEMBL14699223 | 0.80 | GSK3B (0.58) | PDPK1JAK2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL3384896 | 0.79 | PRKAG1 (0.49) | JAK2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL13337374 | 0.78 | PRKAG1 (0.53) | AAK1JAK2PRKAG1PRKAA1PRKAB1 | |
| SCHEMBL5945655 | 0.78 | PRKAA1 (0.72) | JAK2PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL4008217 | 0.76 | PRKAG1 (0.56) | JAK2PRKAG1PRKAA1PRKAB1PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102239150-A | Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient | KOREA INST SCI & TECH | 2011-11-09 | — | — | CN | claimed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | claimed |
| CN-102239150-A | Novel indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient | KOREA INST SCI & TECH | 2011-11-09 | — | — | CN | disclosed |
| WO-2010064875-A2 | NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2010-06-10 | — | — | WO | disclosed |