Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3386790 | 1.00 | ROCK2 (0.68) | ROCK2ROCK1AKT1PRKACAPRKACG | |
| SCHEMBL3389658 | 0.88 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL3386619 | 0.88 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL3386625 | 0.88 | ROCK2 (0.75) | ROCK2ROCK1 | |
| SCHEMBL3383157 | 0.88 | ROCK2 (0.63) | ROCK2ROCK1 | |
| SCHEMBL3383164 | 0.88 | ROCK2 (0.63) | ROCK2ROCK1 | |
| SCHEMBL3387757 | 0.86 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL3387761 | 0.86 | ROCK2 (0.67) | ROCK2ROCK1 | |
| SCHEMBL3387576 | 0.83 | ROCK2 (0.66) | ROCK2ROCK1 | |
| SCHEMBL3387565 | 0.83 | ROCK2 (0.66) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |