Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | TNF | P01375 | 1/20 | 0.57 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CCNC | P24863 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789044 | 0.87 | ATM (0.65) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL2368397 | 0.85 | PRNP (0.64) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL1902142 | 0.84 | ALDH1A1 (0.59) | ALDH1A1RXFP1KDM4ERECQLMAPK1 | |
| SCHEMBL2368421 | 0.77 | MAPK1 (0.63) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL2369277 | 0.77 | CCNC (0.78) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL2368203 | 0.76 | ALDH1A1 (0.69) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL1899788 | 0.76 | ALDH1A1 (0.72) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL3169227 | 0.76 | MAPK1 (0.65) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL1514866 | 0.76 | ATM (0.66) | ALDH1A1RXFP1KDM4EMAPK1TNF | |
| SCHEMBL2368993 | 0.75 | CCNC (0.65) | ALDH1A1RXFP1KDM4EMAPK1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |