Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.43 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1365911 | 0.90 | — | — | |
| Ammonia Solution, Strong SCHEMBL9344809 | 0.87 | ALDH1A1 (0.50) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 | |
| Isopropyl Alcohol SCHEMBL28973856 | 0.81 | ALDH1A1 (0.44) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL40400 | 0.76 | ALDH1A1 (0.60) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL13169682 | 0.75 | — | — | |
| SCHEMBL291263 | 0.75 | — | — | |
| SCHEMBL10402309 | 0.75 | — | — | |
| Trimethylammonium SCHEMBL1045296 | 0.75 | ALDH1A1 (0.48) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 | |
| Trimethylammonium SCHEMBL16161251 | 0.73 | ALDH1A1 (0.46) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL10492632 | 0.73 | CHRM5 (0.60) | ALDH1A1CHRM5CHRM1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3366762-B1 | LARGE SCALE DISPOSABLE BIOREACTOR | PROTALIX LTD (IL) | 2020-07-08 | — | — | EP | disclosed |
| US-10364413-B2 | Large scale disposable bioreactor | PROTALIX LTD. (IL) | 2019-07-30 | — | — | US | disclosed |
| EP-3366762-A1 | LARGE SCALE DISPOSABLE BIOREACTOR | Protalix Ltd. (IL) | 2018-08-29 | — | — | EP | disclosed |
| EP-2150608-B1 | LARGE SCALE DISPOSABLE BIOREACTOR | PROTALIX LTD (IL) | 2017-11-29 | — | — | EP | disclosed |
| US-20100112700-A1 | LARGE SCALE DISPOSABLE BIOREACTOR | PROTALIX LTD. (IL) | 2010-05-06 | — | — | US | disclosed |
| EP-2150608-A2 | LARGE SCALE DISPOSABLE BIOREACTOR | Protalix Ltd. (IL) | 2010-02-10 | — | — | EP | disclosed |
| WO-2008135991-A2 | LARGE SCALE DISPOSABLE BIOREACTOR | PROTALIX LTD. (IL) | 2008-11-13 | — | — | WO | disclosed |