Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1889250 | 0.89 | MEN1 (0.43) | ATMACACAMAPTALDH1A1KDM4E | |
| SCHEMBL3386976 | 0.84 | PIK3CD (0.46) | ATMALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4915121 | 0.76 | PDE10A (0.53) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL1883162 | 0.76 | ALDH1A1 (0.40) | ATMACACAMAPTALDH1A1KDM4E | |
| SCHEMBL19413117 | 0.75 | DHODH (0.46) | ATMKDM4EHPGDPIK3CDMAPK1 | |
| SCHEMBL3387112 | 0.74 | PSMB5 (0.46) | MAPTALDH1A1KDM4EHPGDCYP1A2 | |
| SCHEMBL3383008 | 0.74 | ESR1 (0.40) | ALDH1A1KDM4EHPGDCYP2C9TSHR | |
| SCHEMBL1887862 | 0.72 | MEN1 (0.48) | ATMALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL19864357 | 0.71 | PIK3CD (0.42) | ATMMAPTALDH1A1HPGDCYP1A2 | |
| SCHEMBL3658422 | 0.71 | KDM4E (0.44) | ALDH1A1KDM4ECYP2C9KMT2APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891011-B1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2010-12-08 | — | — | EP | disclosed |
| EP-1891011-A1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006133821-A1 | TETRAHYDROQUINOLINES USED IN THE FORM OF MODULATORS OF MITOTIC MOTOR-PROTEINS EG5 | MERCK PATENT GMBH (DE) | 2006-12-21 | — | — | WO | disclosed |