Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | TNF | P01375 | 2/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.52 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPR1 | P16066 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.40 |
| ▸ | CDK2 | P24941 | 8/20 | 0.40 |
| ▸ | CDK4 | P11802 | 7/20 | 0.40 |
| ▸ | CCND1 | P24385 | 7/20 | 0.40 |
| ▸ | CDK7 | P50613 | 7/20 | 0.40 |
| ▸ | CCNH | P51946 | 7/20 | 0.40 |
| ▸ | CDK1 | P06493 | 6/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368786 | 0.88 | TNF (0.57) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL2368804 | 0.86 | TNF (0.55) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL27660750 | 0.85 | TNF (0.64) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL3386735 | 0.84 | TNF (0.59) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL2369487 | 0.83 | TNF (0.52) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL2368704 | 0.83 | MAPK1 (0.64) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL2369260 | 0.82 | TNF (0.55) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL2368795 | 0.82 | TNF (0.59) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL3385334 | 0.82 | ESR1 (0.61) | MAPK1TNFNOD1KCNA5PIP4K2C | |
| SCHEMBL3384953 | 0.81 | KCNH2 (0.57) | MAPK1TNFNOD1KCNA5PIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |