Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384957 | 0.92 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL2369234 | 0.89 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL3382770 | 0.89 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL3387823 | 0.85 | KDM4E (0.40) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL3384941 | 0.85 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL2369471 | 0.85 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL2368679 | 0.84 | PRKCI (0.38) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL3387832 | 0.82 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL2368222 | 0.81 | PRKCI (0.41) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL3386420 | 0.79 | ALDH1A1 (0.45) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-B3 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2010-12-08 | — | — | EP | disclosed |
| EP-1641803-B1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION LTD (GB) | 2009-03-18 | — | — | EP | disclosed |
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |