Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 10/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.59 |
| ▸ | CDK2 | P24941 | 8/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27686737 | 0.92 | CDK5 (0.68) | CDK5CDK5R1CCNA2CDK2KDM4E | |
| SCHEMBL3384712 | 0.89 | CCNA2 (0.74) | CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL3389650 | 0.86 | CCNA2 (0.53) | CDK5CDK5R1CCNA2CDK2KDM4E | |
| SCHEMBL3386774 | 0.83 | CDK5 (0.72) | CDK5CDK5R1CCNA2CDK2KDM4E | |
| SCHEMBL3386683 | 0.82 | CDK5 (0.74) | CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL3384847 | 0.81 | CDK5 (0.70) | CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL28765719 | 0.81 | CDK5 (0.67) | CDK5CDK5R1CCNA2CDK2KDM4E | |
| SCHEMBL28765718 | 0.81 | CDK5 (0.69) | CDK5CDK5R1CCNA2CDK2KDM4E | |
| SCHEMBL3389148 | 0.79 | CDK2 (0.49) | CDK5CDK5R1CCNA2CDK2GSK3A | |
| SCHEMBL14073849 | 0.79 | CDK5 (0.67) | CDK5CDK5R1CCNA2CDK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771424-B1 | NOVEL 2,4-DIAMINOTHIAZOL-5-ONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-12-15 | — | — | EP | claimed |