Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL517374 | 0.97 | NR1H2 (0.46) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL16903462 | 0.83 | USP2 (0.46) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL27936598 | 0.82 | NR1H2 (0.38) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL15749495 | 0.82 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL30075744 | 0.82 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL23580046 | 0.81 | NR1H2 (0.55) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL29207289 | 0.81 | USP2 (0.41) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL27743952 | 0.81 | USP2 (0.41) | NR1H2USP2SMN1; SMN2ESR2DDB1 | |
| SCHEMBL18420747 | 0.80 | RORC (0.39) | NR1H2ESR2DDB1CRBNADORA1 | |
| SCHEMBL518157 | 0.80 | USP2 (0.42) | NR1H2USP2SMN1; SMN2ESR2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010068881-A1 | NOVEL BENZODIOXANE AND BENZOXAZINE DERIVATIVES USEFUL AS CC CHEMOKINE RECEPTOR LIGANDS | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-06-17 | — | — | WO | disclosed |