Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24495604 | 0.76 | CYP2D6 (0.62) | HRH3CYP2D6CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL3432734 | 0.75 | HRH3 (0.47) | HRH3CYP2D6CYP2C19CNR2CNR1 | |
| SCHEMBL24495602 | 0.74 | HRH3 (0.57) | HRH3CYP2D6CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL3435319 | 0.74 | HRH3 (0.46) | HRH3CYP2D6CYP2C19CNR2CNR1 | |
| SCHEMBL22310287 | 0.74 | S1PR1 (0.50) | HRH3CYP2D6CYP2C19CNR2CNR1 | |
| SCHEMBL23440312 | 0.74 | CYP2D6 (0.68) | HRH3CYP2D6CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL12597039 | 0.74 | CCNB2 (0.51) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL11992422 | 0.73 | PRMT6 (0.48) | HRH3CYP2D6CYP2C19CNR2CNR1 | |
| SCHEMBL3425973 | 0.72 | CYP2D6 (0.65) | HRH3CYP2D6CYP2C19SMN1; SMN2TDP1 | |
| SCHEMBL30572548 | 0.72 | DHODH (0.68) | CNR2CNR1HDAC6SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052448-A2 | FUSED PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-05-14 | — | — | WO | disclosed |