Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30967963 | 0.86 | MAPT (0.43) | L3MBTL1RAB9AMAPTNPSR1MEN1 | |
| SCHEMBL30217390 | 0.86 | MAPT (0.43) | L3MBTL1RAB9AMAPTNPSR1MEN1 | |
| SCHEMBL1057530 | 0.86 | PIK3CD (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL30066410 | 0.86 | PIK3CD (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28683536 | 0.86 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31517088 | 0.86 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL949890 | 0.85 | JMJD6 (0.45) | L3MBTL1RAB9AALDH1A1PIK3CDABL1 | |
| SCHEMBL6394140 | 0.83 | PIK3CD (0.45) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL1623656 | 0.83 | PIK3CD (0.45) | ALDH1A1PIK3CDABL1EGFRHCK | |
| SCHEMBL12043978 | 0.82 | PIK3CD (0.44) | L3MBTL1PIK3CDABL1EGFRHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891049-B1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI SA (FR) | 2017-07-19 | — | — | EP | disclosed |
| EP-2226319-B1 | Process for the preparation of 2-(2-aminopyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | SANOFI SA (FR) | 2016-03-16 | — | — | EP | disclosed |
| US-20140005392-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI (FR) | 2014-01-02 | — | — | US | disclosed |
| US-8546567-B2 | Method for producing 2-(2-aminopyrimidin-4-yl)-1H-indole-5-carboxylic acid derivatives | SANOFI (FR) | 2013-10-01 | — | — | US | disclosed |
| US-20120271051-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI (FR) | 2012-10-25 | — | — | US | disclosed |
| US-8232395-B2 | ethyl 2-(2-chloropyrimidin-4-yl)-1H-indole-5-carboxylate; intermediates for preparing Ikb kinase inhibitors | SANOFI (FR) | 2012-07-31 | — | — | US | disclosed |
| US-8232395-B2 | ethyl 2-(2-chloropyrimidin-4-yl)-1H-indole-5-carboxylate; intermediates for preparing Ikb kinase inhibitors | SANOFI (FR) | 2012-07-31 | — | — | US | disclosed |
| EP-2226319-A1 | Process for the preparation of 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonic acid derivatives | sanofi-aventis (FR) | 2010-09-08 | — | — | EP | disclosed |
| US-20080214813-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-09-04 | — | — | US | disclosed |
| EP-1891049-A1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | Sanofi-Aventis (FR) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128585-A1 | METHOD FOR PRODUCING 2-(2-AMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | SANOFI-AVENTIS (DE) | 2006-12-07 | — | — | WO | disclosed |
| JP-2005112743-A | N-TERT-BUTOXYCARBONYL-5-ETHOXYCARBONYLINDOLE AND METHOD FOR PRODUCING THE SAME | TAOKA CHEM CO LTD | 2005-04-28 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120271051-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | TPH2, IDO2, IDO1 | CA12 1922/4885CA1 1117/4885CA2 1497/4885 |
| US-20080214813-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | TPH2, IDO2, IDO1 | CA12 1593/4885CA1 674/4885CA2 983/4885 |
| US-20140005392-A1 | METHOD FOR PRODUCING 2-(2-AMINOPYRIMIDIN-4-YL)-1H-INDOLE-5-CARBOXYLIC ACID DERIVATIVES | TPH2, IDO2, IDO1 | CA12 1922/4885CA1 1117/4885CA2 1497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.