Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 7/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 7/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 7/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3180417 | 0.87 | MAPK14 (0.37) | MAPK14MAPK12HCKMAPK13MAPK11 | |
| SCHEMBL3392522 | 0.87 | MAPK14 (0.36) | MAPK14MAPK12HCKSRCMAPK13 | |
| SCHEMBL3387978 | 0.85 | KCNJ6 (0.49) | KCNJ6KCNJ5KCNJ3MAPK14MAPK12 | |
| SCHEMBL3389381 | 0.82 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3MAPK14MAPK12 | |
| SCHEMBL3388827 | 0.80 | MAPK14 (0.38) | KCNJ6KCNJ5KCNJ3MAPK14MAPK12 | |
| SCHEMBL3422863 | 0.79 | KCNJ6 (0.40) | KCNJ6KCNJ5KCNJ3MAPK14MAPK12 | |
| SCHEMBL3170652 | 0.79 | MAPK14 (0.36) | MAPK14MAPK12SRCMAPK13SYK | |
| SCHEMBL3170645 | 0.74 | MAPK14 (0.49) | MAPK14MAPK12MAPK13MAPK11 | |
| SCHEMBL4468019 | 0.74 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3MAPK14MAPK12 | |
| SCHEMBL4481650 | 0.72 | MAPK14 (0.37) | MAPK14MAPK12HCKSRCMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |