Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.73 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.73 |
| ▸ | MAP4K3 | Q8IVH8 | 6/20 | 0.73 |
| ▸ | JAK2 | O60674 | 5/20 | 0.73 |
| ▸ | JAK3 | P52333 | 3/20 | 0.73 |
| ▸ | PLK4 | O00444 | 2/20 | 0.73 |
| ▸ | AURKA | O14965 | 2/20 | 0.73 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.73 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.73 |
| ▸ | ABL1 | P00519 | 2/20 | 0.73 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.73 |
| ▸ | INSR | P06213 | 2/20 | 0.73 |
| ▸ | LCK | P06239 | 2/20 | 0.73 |
| ▸ | FES | P07332 | 2/20 | 0.73 |
| ▸ | CSF1R | P07333 | 2/20 | 0.73 |
| ▸ | LYN | P07948 | 2/20 | 0.73 |
| ▸ | RET | P07949 | 2/20 | 0.73 |
| ▸ | IGF1R | P08069 | 2/20 | 0.73 |
| ▸ | ROS1 | P08922 | 2/20 | 0.73 |
| ▸ | SRC | P12931 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1581714 | 0.94 | MET (0.76) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL13005800 | 0.93 | MET (0.71) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL30751188 | 0.92 | MET (0.69) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL3387217 | 0.90 | MET (0.76) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL19718102 | 0.90 | MET (0.76) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL14821427 | 0.90 | MET (0.78) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL16085088 | 0.90 | MET (0.78) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL3391037 | 0.90 | MET (0.78) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL30751189 | 0.90 | MET (0.67) | METALKMAP4K3JAK2JAK3 | |
| SCHEMBL30751244 | 0.90 | MET (0.67) | METALKMAP4K3JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214227-A | Heterocyclic compound and application thereof | 上海青玄生物科技有限公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-111285849-A | Compound for targeted degradation of ALK, c-Met and ROS1 proteins and preparation method thereof | 上海青东生物科技有限公司 | 2020-06-16 | — | — | CN | disclosed |
| EP-1784396-B1 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-12-22 | — | — | EP | disclosed |
| EP-1784396-A2 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | Pfizer, Inc. (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021881-A2 | PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER INC. (US) | 2006-03-02 | — | — | WO | disclosed |