Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391221 | 1.00 | KCNH2 (0.52) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL13945285 | 1.00 | KCNH2 (0.52) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL3389912 | 1.00 | KCNH2 (0.52) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL2182240 | 0.93 | KCNH2 (0.54) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL2184563 | 0.93 | KCNH2 (0.54) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL2183543 | 0.92 | KCNH2 (0.53) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL2183969 | 0.91 | KCNH2 (0.53) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL3388157 | 0.89 | KCNH2 (0.65) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL3391311 | 0.89 | KCNH2 (0.41) | KCNH2ALDH1A1POLBCHRM2CHRM1 | |
| SCHEMBL6951491 | 0.89 | KCNH2 (0.56) | KCNH2ALDH1A1POLBOPRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | claimed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | claimed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | claimed |
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | disclosed |
| EP-1857453-B1 | FLUOROALKYLPYRROLIDINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-12-29 | — | — | EP | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY LIMITED (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
| EP-1857453-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012119-A1 | FLUOROALKYLPYRROLIDINE DERIVATIVE | FPR1, VIP, Q6ZSR9 | KCNH2 139/4885ALDH1A1 2123/4885POLB 1236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.