Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.46 |
| ▸ | NFATC1 | O95644 | 6/20 | 0.46 |
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21917173 | 0.87 | DYRK1A (0.43) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL21917362 | 0.84 | DYRK1A (0.46) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL253653 | 0.83 | DYRK1A (0.67) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL21917360 | 0.81 | DYRK1A (0.44) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL4858180 | 0.81 | DYRK1A (0.46) | DYRK1ANFATC1GSK3BCNR2CNR1 | |
| SCHEMBL21917170 | 0.79 | TBXAS1 (0.46) | DYRK1ANFATC1GSK3BCNR2CNR1 | |
| SCHEMBL4851744 | 0.79 | DYRK1A (0.49) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL15388885 | 0.78 | HASPIN (0.61) | DYRK1ANFATC1GSK3BHASPINKCNH2 | |
| SCHEMBL4857118 | 0.77 | DYRK1A (0.57) | DYRK1ANFATC1GSK3BHASPINCNR2 | |
| SCHEMBL14203016 | 0.76 | CNR2 (0.57) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000595-A1 | 2,4- DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |