Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL4453838 | 0.93 | ALDH1A1 (0.54) | TSHRALDH1A1THRBCA2HPGD | |
| Acetic Acid SCHEMBL18812928 | 0.91 | ALDH1A1 (0.52) | TSHRALDH1A1THRBCA2HPGD | |
| Bicarbonate SCHEMBL30051784 | 0.89 | ALDH1A1 (0.59) | TSHRALDH1A1THRBHPGDNPC1 | |
| Bicarbonate SCHEMBL377470 | 0.89 | ALDH1A1 (0.59) | TSHRALDH1A1THRBHPGDNPC1 | |
| Bicarbonate SCHEMBL9083427 | 0.89 | ALDH1A1 (0.44) | TSHRALDH1A1CA2SMN1; SMN2CYP3A4 | |
| Bicarbonate SCHEMBL27364872 | 0.89 | ALDH1A1 (0.44) | TSHRALDH1A1CA2SMN1; SMN2CYP3A4 | |
| Succinic Acid SCHEMBL3686657 | 0.89 | ALDH1A1 (0.48) | TSHRALDH1A1THRBEPHX2BLM | |
| SCHEMBL16546828 | 0.87 | ALDH1A1 (0.45) | TSHRALDH1A1THRBCA2CYP3A4 | |
| SCHEMBL14134607 | 0.87 | ALDH1A1 (0.45) | TSHRALDH1A1THRBCA2CYP3A4 | |
| SCHEMBL316251 | 0.87 | ALDH1A1 (0.45) | TSHRALDH1A1THRBCA2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2143689-A1 | Dispersion containing indium-tin oxide particles | Evonik Degussa GmbH (DE) | 2010-01-13 | — | — | EP | disclosed |