Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.47 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389283 | 1.00 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1C1ALDH1A1TSHR | |
| SCHEMBL2654404 | 0.87 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2654402 | 0.87 | AKR1C3 (0.50) | AKR1C3AKR1C2AKR1C1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2652745 | 0.86 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2652741 | 0.86 | AKR1C3 (0.49) | AKR1C3AKR1C2AKR1C1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3390564 | 0.81 | NPC1 (0.41) | AKR1C3ALDH1A1TSHRSMN1; SMN2GCK | |
| SCHEMBL2665989 | 0.81 | GCK (0.41) | AKR1C1GCKKMT2A | |
| SCHEMBL3390559 | 0.81 | NPC1 (0.41) | AKR1C3ALDH1A1TSHRSMN1; SMN2GCK | |
| SCHEMBL2656286 | 0.81 | GCK (0.40) | ALDH1A1MAPK1SMN1; SMN2GCK | |
| SCHEMBL3393082 | 0.81 | ALDH1A1 (0.45) | AKR1C3ALDH1A1GCKKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168962-A2 | PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE MODULATORS | Prosidion Limited (GB) | 2010-03-31 | — | — | EP | disclosed |
| US-7214681-B2 | Tri(cyclo) substituted amide compounds | PROSIDION LIMITED (GB) | 2007-05-08 | — | — | US | disclosed |