Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 6/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389109 | 1.00 | HRH1 (0.56) | HRH1HTR2ASIGMAR1CYP19A1TBXAS1 | |
| SCHEMBL2091869 | 0.98 | HRH1 (0.58) | HRH1HTR2ASIGMAR1CYP19A1TBXAS1 | |
| SCHEMBL2096612 | 0.91 | HRH1 (0.60) | HRH1HTR2ASIGMAR1CYP19A1TAAR1 | |
| SCHEMBL9073997 | 0.85 | HRH1 (0.71) | HRH1HTR2ASIGMAR1CYP19A1TAAR1 | |
| SCHEMBL8847425 | 0.84 | HRH1 (0.39) | HRH1HTR2ASIGMAR1CYP19A1TAAR1 | |
| SCHEMBL8847370 | 0.84 | HRH1 (0.39) | HRH1HTR2ASIGMAR1CYP19A1TBXAS1 | |
| SCHEMBL8157930 | 0.83 | HRH1 (0.38) | HRH1HTR2ASIGMAR1CYP19A1TBXAS1 | |
| SCHEMBL11234621 | 0.83 | RIPK1 (0.50) | — | |
| SCHEMBL10989395 | 0.81 | RIPK1 (0.50) | SIGMAR1TAAR1 | |
| SCHEMBL3391511 | 0.81 | RIPK1 (0.50) | SIGMAR1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |