Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264062 | 0.87 | ATR (0.44) | METAP1BRD9ELANECTRB1BRD4 | |
| SCHEMBL4908993 | 0.83 | BRD4 (0.44) | METAP1BRD4MEN1KMT2ARAB9A | |
| SCHEMBL21232354 | 0.79 | BRD9 (0.39) | METAP1BRD9ELANECTRB1BRD4 | |
| SCHEMBL20328515 | 0.79 | RAB9A (0.42) | MEN1KMT2ANPC1RAB9AHTT | |
| SCHEMBL4909182 | 0.78 | METAP1 (0.45) | METAP1LCK | |
| SCHEMBL4908439 | 0.78 | METAP1 (0.45) | METAP1MEN1KMT2AATRMAPT | |
| SCHEMBL4908445 | 0.78 | CYP17A1 (0.41) | METAP1BRD9ELANECTRB1KMT2A | |
| SCHEMBL27690446 | 0.77 | CYP17A1 (0.39) | METAP1BRD9ELANECTRB1BRD4 | |
| SCHEMBL27706880 | 0.77 | ELANE (0.44) | BRD9ELANECTRB1BRD4MEN1 | |
| SCHEMBL4907676 | 0.77 | GRM5 (0.50) | METAP1NPC1RAB9AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010072722-A1 | PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010063663-A1 | N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL] METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2010-06-10 | — | — | WO | disclosed |