Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 5/20 | 0.54 |
| ▸ | IGF1R | P08069 | 9/20 | 0.52 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAC1 | P63000 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392739 | 0.89 | CCR4 (0.54) | CCR4IGF1RKCNH3CACNA2D1MAPT | |
| SCHEMBL879557 | 0.78 | CCR4 (0.53) | CCR4KCNH3EGFRMAPTRAC1 | |
| SCHEMBL3389537 | 0.77 | RAC1 (0.68) | CCR4KCNH3CACNA2D1MAPTRAC1 | |
| SCHEMBL3389001 | 0.77 | CCR4 (0.52) | CCR4KCNH3MAPTRAC1 | |
| SCHEMBL29920803 | 0.77 | RAC1 (0.54) | CCR4KCNH3CACNA2D1MAPTRAC1 | |
| SCHEMBL20966325 | 0.77 | RAC1 (0.54) | CCR4KCNH3CACNA2D1MAPTRAC1 | |
| SCHEMBL3393939 | 0.76 | CCR4 (0.53) | CCR4KCNH3EGFRMAPTRAC1 | |
| SCHEMBL13868216 | 0.75 | RAC1 (0.81) | CCR4KCNH3CACNA2D1MAPTRAC1 | |
| SCHEMBL6313422 | 0.73 | IGF1R (0.60) | IGF1REGFRINSRMETCDK2 | |
| SCHEMBL8183557 | 0.71 | CACNA2D1 (0.64) | CCR4CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | claimed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | claimed |
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010119050-A1 | NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | WO | disclosed |
| EP-2241555-A1 | New RAC1 inhibitors as potential pharmacological agents for heart failure treatment | UNIVERSITA' DEGLI STUDI DI MILANO (IT) | 2010-10-20 | — | — | EP | disclosed |