Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.54 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6311579 | 0.80 | AURKA (0.73) | IGF1RAURKAAURKBCDK2EGFR | |
| Hydrochloric Acid SCHEMBL15966728 | 0.76 | IGF1R (0.53) | IGF1RAURKAAURKBCDK2CCNT1 | |
| SCHEMBL4820777 | 0.76 | CDK2 (0.55) | IGF1RAURKAAURKBCDK2CCNT1 | |
| SCHEMBL7469727 | 0.76 | CDK2 (0.59) | IGF1RCDK2CCNT1CCNA2CDK9 | |
| SCHEMBL4457626 | 0.75 | IGF1R (0.75) | IGF1RAURKAAURKBCDK2CCNT1 | |
| SCHEMBL6312261 | 0.75 | IGF1R (0.60) | IGF1RAURKAAURKBCDK2EGFR | |
| SCHEMBL6311161 | 0.74 | IGF1R (0.66) | IGF1RAURKACDK2EGFRINSR | |
| SCHEMBL3389918 | 0.73 | CCR4 (0.54) | IGF1RCDK2EGFRINSRMET | |
| SCHEMBL15922813 | 0.73 | DNMT1 (0.63) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL6312556 | 0.73 | IGF1R (0.69) | IGF1RAURKACDK2EGFRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939874-B2 | Substituted pyrimidinyl derivatives and methods of use | AMGEN INC. (US) | 2005-09-06 | — | — | US | disclosed |