⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28716308 | 0.92 | EPHX1 (0.33) | — | |
| SCHEMBL25174321 | 0.86 | — | — | |
| SCHEMBL6860756 | 0.78 | — | — | |
| SCHEMBL28707167 | 0.72 | KDM4E (0.33) | — | |
| SCHEMBL29096872 | 0.72 | KDM4E (0.33) | — | |
| SCHEMBL28703763 | 0.67 | CES2 (0.35) | — | |
| SCHEMBL29057704 | 0.67 | KDM4E (0.38) | — | |
| SCHEMBL1385536 | 0.65 | — | — | |
| SCHEMBL4388566 | 0.65 | — | — | |
| SCHEMBL1302634 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0083378-A1 | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-07-13 | — | — | EP | claimed |
| US-4361572-A | Tetrahydronicotinamide derivative, pharmaceutical compositions and use | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-11-30 | — | — | US | claimed |
| US-8980907-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-8889635-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140128327-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-08 | — | — | US | disclosed |
| US-20100160299-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-06-24 | — | — | US | disclosed |
| WO-2010039861-A2 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-04-08 | — | — | WO | disclosed |
| EP-2101768-A2 | USE OF NEUROPROTECTIVE COMPOUNDS FOR OBTAINING DRUGS FOR TREATING NEURODEGENERATIVE DISEASES | Les Laboratoires Servier (FR) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008099083-A2 | USE OF NEUROPROTECTIVE COMPOUNDS FOR OBTAINING DRUGS FOR TREATING NEURODEGENERATIVE DISEASES | LES LABORATOIRES SERVIER (FR) | 2008-08-21 | — | — | WO | disclosed |
| EP-0083378-A1 | Tetrahydronicotinamide derivatives, a process for producing the same and a pharmaceutical composition comprising the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-07-13 | — | — | EP | disclosed |
| US-4361572-A | Tetrahydronicotinamide derivative, pharmaceutical compositions and use | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1982-11-30 | — | — | US | disclosed |