Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27829697 | 0.97 | TSHR (0.35) | TSHRLMNATHRBFDPSDNM1 | |
| Bromide SCHEMBL27305162 | 0.97 | TSHR (0.35) | TSHRLMNATHRBFDPSDNM1 | |
| SCHEMBL93520 | 0.97 | TSHR (0.40) | TSHRLMNATHRBFDPSESR1 | |
| Bromide SCHEMBL5084903 | 0.94 | TSHR (0.39) | TSHRLMNATHRBFDPSDNM1 | |
| Hydrochloric Acid SCHEMBL967604 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSDNM1 | |
| SCHEMBL30656569 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSESR1 | |
| Ammonia Solution, Strong SCHEMBL27282069 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSESR1 | |
| Water SCHEMBL553356 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSESR1 | |
| Iodide SCHEMBL553390 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSESR1 | |
| SCHEMBL28173240 | 0.93 | TSHR (0.38) | TSHRLMNATHRBFDPSESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11549134-B2 | Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same | KIKKOMAN CORPORATION (JP) | 2023-01-10 | — | — | US | claimed |
| US-20200263228-A1 | MODIFIED AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING THE SAME | KIKKOMAN CORPORATION (JP) | 2020-08-20 | — | — | US | claimed |
| US-20160186232-A1 | MODIFIED AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING THE SAME | KIKKOMAN CORPORATION (JP) | 2016-06-30 | — | — | US | claimed |
| EP-3031914-A1 | MODIFIED AMADORIASE AND METHOD FOR PRODUCING SAME, AGENT FOR IMPROVING SURFACTANT-RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HbA1c USING SAME | Kikkoman Corporation (JP) | 2016-06-15 | — | — | EP | claimed |
| WO-2025121285-A1 | PHOSPHINE-PALLADIUM COMPLEX, POLYMERIZATION CATALYST, AND METHOD FOR PRODUCING AROMATIC POLYMER | 日本化学工業株式会社 | 2025-06-12 | — | — | WO | disclosed |
| EP-3279323-B1 | AMADORIASE HAVING IMPROVED SPECIFIC ACTIVITY | KIKKOMAN CORP (JP) | 2023-03-08 | — | — | EP | disclosed |
| US-11549134-B2 | Modified amadoriase and method for producing the same, agent for improving surfactant resistance of amadoriase and composition for measuring HbA1c using the same | KIKKOMAN CORPORATION (JP) | 2023-01-10 | — | — | US | disclosed |
| CN-114308064-A | Hierarchical porous solid material confinement metal-based catalyst and preparation method and application thereof | 东北电力大学 | 2022-04-12 | — | — | CN | disclosed |
| EP-3604354-B1 | PRODUCTION METHOD FOR POLYMER | DAINICHISEIKA COLOR CHEM (JP) | 2022-02-02 | — | — | EP | disclosed |
| US-10995159-B2 | Production method for polymer | DAINICHISEIKA COLOR & CHEMICALS MFG. CO., LTD. (JP) | 2021-05-04 | — | — | US | disclosed |
| US-10934530-B2 | Amadoriase having improved specific activity | KIKKOMAN CORPORATION (JP) | 2021-03-02 | — | — | US | disclosed |
| EP-3760717-A1 | AMADORIASE AND METHOD FOR PRODUCING THE SAME, AGENT FOR IMPROVING SURFACTANT RESISTANCE OF AMADORIASE AND COMPOSITION FOR MEASURING HBA1C USING THE SAME | Kikkoman Corporation (JP) | 2021-01-06 | — | — | EP | disclosed |
| US-4758673-A | 1-aryl-5-halopyrazoles | BAYER AKTIENGESELLSCHAFT (DE) | 1988-07-19 | — | — | US | disclosed |
| US-4747867-A | 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and herbicidal method of using them | BAYER AKTIENGESELLSCHAFT (DE) | 1988-05-31 | — | — | US | disclosed |
| US-4681618-A | 1-aryl-5-halo-4-nitopyrazoles, herbicidal compositions containing them, and herbicidal method of using them | BAYER AKTIENGESELLSCHAFT (DE) | 1987-07-21 | — | — | US | disclosed |
| US-4405766-A | Phosphonium bicarbonate catalysts for promoting reaction of epoxides with carboxylic acids or anhydrides | THE DOW CHEMICAL COMPANY (US) | 1983-09-20 | — | — | US | disclosed |
| US-4354015-A | HIGH MOLECULAR WEIGHT LINEAR EPOXY RESINS | THE DOW CHEMICAL COMPANY (US) | 1982-10-12 | — | — | US | disclosed |
| US-4321395-A | Preparation of acetanilides | BASF AKTIENGESELLSCHAFT (DE) | 1982-03-23 | — | — | US | disclosed |
| US-4284573-A | Preparation of glycidyl ethers | THE DOW CHEMICAL COMPANY (US) | 1981-08-18 | — | — | US | disclosed |
| US-4235928-A | Substituted cyanamides and their use as fungicides | BASF AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | disclosed |