Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395455 | 0.69 | HIF1A (1.00) | HIF1APTPN1 | |
| SCHEMBL6005107 | 0.64 | HIF1A (0.34) | HIF1A | |
| SCHEMBL3388767 | 0.63 | CYP11B1 (0.42) | HIF1APTPN1 | |
| SCHEMBL3394201 | 0.62 | CYP19A1 (0.34) | — | |
| SCHEMBL13443047 | 0.61 | HIF1A (0.44) | HIF1A | |
| SCHEMBL13443048 | 0.59 | HIF1A (0.35) | HIF1A | |
| SCHEMBL1106477 | 0.59 | HIF1A (0.45) | HIF1A | |
| SCHEMBL20664871 | 0.57 | HIF1A (0.44) | HIF1A | |
| SCHEMBL23760241 | 0.57 | HIF1A (0.43) | HIF1A | |
| SCHEMBL7371700 | 0.55 | HIF1A (0.41) | HIF1APTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | claimed |
| US-20100087478-A1 | HIF-1 Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-04-08 | — | — | US | disclosed |
| US-7652033-B2 | HIF-1 inhibitors | EMORY UNIVERSITY (US) | 2010-01-26 | — | — | US | disclosed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
| US-20070099952-A1 | Hif-1 inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099952-A1 | Hif-1 inhibitors | HIF1AN, HIF1A, EGLN2 | HIF1A 2/4885PTPN1 3949/4885 |
| US-20100087478-A1 | HIF-1 Inhibitors | HIF1AN, HIF1A, EGLN2 | HIF1A 2/4885PTPN1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.