Clentiazem

Clentiazem

SCHEMBL33909

COc1ccc([C@@H]2Sc3cc(Cl)ccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1S Q13698 12/20 0.86
CYP3A4 P08684 3/20 0.77
TSHR P16473 2/20 0.77
ABCB11 O95342 2/20 0.77
LMNA P02545 2/20 0.77
KCNH2 Q12809 2/20 0.77
SLC22A1 O15245 1/20 0.77
CACNA1F O60840 1/20 0.77
ABCB1 P08183 1/20 0.77
HRH2 P25021 1/20 0.77
ADRA1A P35348 1/20 0.77
SCN1A P35498 1/20 0.77
SCN4A P35499 1/20 0.77
HTT P42858 1/20 0.77
SCN7A Q01118 1/20 0.77
CACNA1D Q01668 1/20 0.77
PLAUR Q03405 1/20 0.77
CACNA1C Q13936 1/20 0.77
SCN5A Q14524 1/20 0.77
SCN9A Q15858 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clentiazem SCHEMBL7432489 1.00 CACNA1S (0.86) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL6616493 1.00 CACNA1S (0.86) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL33910 1.00 CACNA1S (0.86) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL10830378 0.99 CACNA1S (0.85) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL10830375 0.99 CACNA1S (0.85) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL10830381 0.99 CACNA1S (0.85) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL9296639 0.96 CACNA1S (0.80) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL387183 0.95 CACNA1S (0.79) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL387182 0.95 CACNA1S (0.79) CACNA1SCYP3A4TSHRABCB11LMNA
Clentiazem SCHEMBL7266655 0.95 CACNA1S (0.79) CACNA1SCYP3A4TSHRABCB11LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2979 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206779-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF UNIVERSIDAD DE CHILE (CL) 2025-06-26 US claimed
WO-2025050228-A1 PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDE OR A COMBINATION OF PEPTIDES AGONISTIC TO THE MAS, AT1 AND AT2 RECEPTORS PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) 2025-03-13 WO claimed
US-20240299348-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE CARAWAY THERAPEUTICS, INC. 2024-09-12 US claimed
EP-4337675-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Universidad De Chile (CL) 2024-03-20 EP claimed
WO-2023183932-A2 MONOBODIES BINDING TO INTERCELLULAR ADHESION MOLECULE 2 (ICAM-2) NEW YORK UNIVERSITY (US) 2023-09-28 WO claimed
WO-2022238734-A1 ANGIOTENSIN-(1-9) ANALOGUE BASED ON D AMINO ACIDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF UNIVERSIDAD DE CHILE (CL) 2022-11-17 WO claimed
CN-115048361-A Big data-based database operation and maintenance risk early warning system and method 南京基石数据技术有限责任公司 2022-09-13 CN claimed
WO-2022150461-A1 MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE CARAWAY THERAPEUTICS, INC. (US) 2022-07-14 WO claimed
EP-3485908-B1 THERAPEUTIC COMBINATION AND USE OF DLL4 ANTAGONIST ANTIBODIES AND ANTI-HYPERTENSIVE AGENTS MEREO BIOPHARMA 5 INC (US) 2021-08-18 EP claimed
CN-112069136-A Outsourcing model mining method for emergency handling process of emergency event 山东理工大学 2020-12-11 CN claimed
WO-1989011281-A1 METHOD OF AMELIORATING EPILEPTIC SEIZURES MARION LABORATORIES, INC. (US) 1989-11-30 WO claimed
US-4879289-A CALCIUM CHANNEL BLOCKERS MARION LABORATORIES, INC. (US) 1989-11-07 US claimed
US-4822789-A ADMINISTERING 2(4-METHOXYPHENYL)-3-ACETOXY-5- 2(DIMETHYLAMINO) ETHYL!-8-CHLORO-2,3-DYHYDRO-1,5-BENZOTHIAZEPIN-(5H)-ONE TANABE SEIYAKU CO., LTD. (JP) 1989-04-18 US claimed
US-4786634-A ADMINISTERING AN 8-CHLORO-1,5-BENZOTHIAZEPINE DERIVATIVE Tanabe Seikyaku Co., Ltd. (JP) 1988-11-22 US claimed
US-4778791-A INCREASING RATIO OF HIGH DENSITY LIPOPROTEINS TANABE SEIYAKU CO., LTD. (JP) 1988-10-18 US claimed
EP-0250814-A2 Prophylactic and curing composition containing a 8-chlorobenzothiazepine compound and its use TANABE SEIYAKU CO., LTD. (JP) 1988-01-07 EP claimed
EP-0246573-A2 Pharmaceutical composition containing a 8-chlorobenzothiazepine compound and its use TANABE SEIYAKU CO., LTD. (JP) 1987-11-25 EP claimed
EP-0127882-B1 NOVEL 8-CHLORO-1,5-BENZOTHIAZEPINE DERIVATIVES, PROCESSES FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS Tanabe Seiyaku Co., Ltd. (JP) 1986-10-15 EP claimed
US-4567175-A HYPOTENSIVE AGENTS, CORONARY OR CEREBRAL VASODILATORS TANABE SEIYAKU CO., LTD. (JP) 1986-01-28 US claimed
EP-0127882-A1 Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions Tanabe Seiyaku Co., Ltd. (JP) 1984-12-12 EP claimed