Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1S | Q13698 | 12/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.77 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.77 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.77 |
| ▸ | HRH2 | P25021 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | SCN1A | P35498 | 1/20 | 0.77 |
| ▸ | SCN4A | P35499 | 1/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.77 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.77 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.77 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.77 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.77 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.77 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clentiazem SCHEMBL33909 | 1.00 | CACNA1S (0.86) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL7432489 | 1.00 | CACNA1S (0.86) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL33910 | 1.00 | CACNA1S (0.86) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL10830378 | 0.99 | CACNA1S (0.85) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL10830375 | 0.99 | CACNA1S (0.85) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL10830381 | 0.99 | CACNA1S (0.85) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL9296639 | 0.96 | CACNA1S (0.80) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL387183 | 0.95 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL387182 | 0.95 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA | |
| Clentiazem SCHEMBL7266655 | 0.95 | CACNA1S (0.79) | CACNA1SCYP3A4TSHRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087953-B1 | NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES | NICOX SA (FR) | 2004-11-17 | — | — | EP | claimed |
| EP-1087953-B1 | NITRATE SALTS OF ANTIHYPERTENSIVE MEDICINES | NICOX SA (FR) | 2004-11-17 | — | — | EP | disclosed |
| US-20040147575-A1 | Nitrate salts of antihypertensive medicines | NICOX S.A. | 2004-07-29 | — | — | US | disclosed |
| US-6645965-B1 | Sildenafil, hydralazine, minoxidil, or zaprinast; cardiovascular disorders | NICOX S.A. (FR) | 2003-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147575-A1 | Nitrate salts of antihypertensive medicines | NOS2, NOS1, NOS3 | CACNA1S 105/4885CYP3A4 277/4885TSHR 2825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.