Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | ADH1C | P00326 | 1/20 | 0.36 |
| ▸ | ADH1A | P07327 | 1/20 | 0.36 |
| ▸ | ADH4 | P08319 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042695 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL3033547 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL6162438 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL6159262 | 1.00 | TSHR (0.44) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL920271 | 0.97 | — | — | |
| SCHEMBL1524591 | 0.91 | TSHR (0.41) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL6163254 | 0.91 | TSHR (0.41) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL1534018 | 0.91 | TSHR (0.41) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL6159886 | 0.91 | TSHR (0.41) | TSHRTHRBFAAHTRPV1DNM1 | |
| SCHEMBL9213664 | 0.91 | TSHR (0.41) | TSHRTHRBFAAHTRPV1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |