Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 10/20 | 0.53 |
| ▸ | KCNJ5 | P48544 | 10/20 | 0.53 |
| ▸ | KCNJ3 | P48549 | 10/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392491 | 0.91 | KCNJ6 (0.48) | KCNJ6KCNJ5KCNJ3BRAFPTK2B | |
| SCHEMBL3164535 | 0.88 | KCNJ6 (0.56) | KCNJ6KCNJ5KCNJ3PTK2BMAPK14 | |
| SCHEMBL3421992 | 0.84 | MAPK14 (0.49) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3164715 | 0.84 | MAPK14 (0.58) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL3170506 | 0.83 | MAPK14 (0.57) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3393257 | 0.83 | KCNJ6 (0.49) | KCNJ6KCNJ5KCNJ3BRAFPTK2B | |
| SCHEMBL3388799 | 0.82 | KCNJ6 (0.49) | KCNJ6KCNJ5KCNJ3BRAFPTK2B | |
| Hydrochloric Acid SCHEMBL3388074 | 0.81 | MAPK14 (0.49) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL3164661 | 0.81 | MAPK14 (0.51) | BRAFPTK2BMAPK14MAPK13MAPK12 | |
| SCHEMBL3394326 | 0.77 | KCNJ6 (0.47) | KCNJ6KCNJ5KCNJ3BRAFPTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |