Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ6 | P48051 | 11/20 | 0.48 |
| ▸ | KCNJ5 | P48544 | 11/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 11/20 | 0.48 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390962 | 0.91 | KCNJ6 (0.53) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3394326 | 0.86 | KCNJ6 (0.47) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3391094 | 0.85 | KCNJ6 (0.47) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3392551 | 0.85 | KCNJ6 (0.42) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3389950 | 0.85 | KCNJ6 (0.52) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3390975 | 0.84 | MAPK14 (0.52) | BRAFMAPK14TNFPTK2BMAPK13 | |
| SCHEMBL3390667 | 0.83 | KCNJ6 (0.45) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3392130 | 0.83 | KCNJ6 (0.41) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3392426 | 0.83 | KCNJ6 (0.50) | KCNJ6KCNJ5KCNJ3BRAFMAPK14 | |
| SCHEMBL3164535 | 0.79 | KCNJ6 (0.56) | KCNJ6KCNJ5KCNJ3MAPK14PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943243-B1 | KINASE INHIBITORS | LILLY CO ELI (US) | 2010-12-29 | — | — | EP | disclosed |