Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24235249 | 0.81 | KDM4E (0.46) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL14190553 | 0.80 | PDE4D (0.56) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL3389520 | 0.79 | KDM4E (0.43) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL24229932 | 0.78 | PDE4D (0.53) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL11093184 | 0.73 | ALDH1A1 (0.50) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL24906337 | 0.73 | KDM4E (0.47) | KDM4EPOLBPDE4DALDH1A1KMT2A | |
| SCHEMBL28892546 | 0.72 | PDE4D (0.54) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL8354129 | 0.72 | KDM4E (0.49) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL28577499 | 0.71 | KDM4E (0.48) | KDM4EPOLBPDE4DALDH1A1HPGD | |
| SCHEMBL3463424 | 0.71 | KDM4E (0.44) | KDM4EPOLBPDE4DALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |