Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3394215 | 0.99 | GRM2 (0.45) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| SCHEMBL13070089 | 0.99 | GRM2 (0.46) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL3391883 | 0.98 | GRM2 (0.45) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| SCHEMBL3707380 | 0.91 | GRM2 (0.42) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| SCHEMBL3392621 | 0.91 | GRM2 (0.42) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| SCHEMBL13070030 | 0.90 | GRM2 (0.41) | GRM2ALDH1A1TSHRACHEBCHE | |
| Hydrochloric Acid SCHEMBL3395856 | 0.90 | GRM2 (0.42) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL3394430 | 0.90 | GRM2 (0.42) | GRM2ALDH1A1TSHRCHRM2CHRM1 | |
| SCHEMBL3708366 | 0.90 | GRM2 (0.41) | GRM2ALDH1A1TSHRSLC2A1DRD2 | |
| Hydrochloric Acid SCHEMBL3396770 | 0.89 | GRM2 (0.40) | GRM2ALDH1A1TSHRACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | claimed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |