Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3396785 | 0.99 | GRM2 (0.41) | GRM2SIGMAR1TRPM8HTR1ADRD2 | |
| SCHEMBL13070089 | 0.90 | GRM2 (0.46) | GRM2DRD2DRD3SLC2A1ALDH1A1 | |
| SCHEMBL3391552 | 0.90 | GRM2 (0.45) | GRM2DRD2DRD3SLC2A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3391883 | 0.90 | GRM2 (0.45) | GRM2DRD2DRD3SLC2A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3394215 | 0.89 | GRM2 (0.45) | GRM2DRD2DRD3SLC2A1ALDH1A1 | |
| SCHEMBL3715589 | 0.84 | GRM2 (0.37) | GRM2TRPM8HTR1ADRD2DRD1 | |
| Hydrochloric Acid SCHEMBL3395503 | 0.83 | GRM2 (0.37) | GRM2TRPM8HTR1ADRD2DRD1 | |
| SCHEMBL13070030 | 0.82 | GRM2 (0.41) | GRM2ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL3396770 | 0.81 | GRM2 (0.40) | GRM2ALDH1A1TSHR | |
| SCHEMBL3707380 | 0.81 | GRM2 (0.42) | GRM2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | claimed |
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |
| WO-2010081904-A1 | 4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS | GLAXO GROUP LIMITED (GB) | 2010-07-22 | — | — | WO | disclosed |