Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499775 | 1.00 | GPR84 (0.38) | GPR84MAOADRD2DRD4DRD3 | |
| SCHEMBL4687381 | 0.98 | GPR84 (0.35) | GPR84MAOADRD2DRD4DRD3 | |
| SCHEMBL269445 | 0.91 | — | — | |
| SCHEMBL8955030 | 0.89 | GPR84 (0.44) | GPR84MAOADRD2DRD4DRD3 | |
| SCHEMBL7003873 | 0.87 | GPR84 (0.41) | GPR84MAOADRD2DRD4DRD3 | |
| SCHEMBL269227 | 0.82 | — | — | |
| SCHEMBL25406384 | 0.79 | DAO (0.39) | GPR84MAOA | |
| SCHEMBL7976680 | 0.79 | GPR84 (0.38) | GPR84MAOADRD2DRD4DRD3 | |
| SCHEMBL5251062 | 0.79 | HRH1 (0.48) | MAOAHRH3 | |
| SCHEMBL25423256 | 0.79 | GPR84 (0.38) | GPR84MAOADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094721-A1 | PIPERIDIN-PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H4 RECEPTOR | PALAU PHARMA, S. A. (ES) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010043633-A1 | 2H-PYRAZOLO [4,3-D]PYRIMIDIN-5-AMINE DERIVATIVES AS H4 HISTAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC, IMMUNOLOGICAL AND INFLAMMATORY DISEASES | PALAU PHARMA, S. A. (ES) | 2010-04-22 | — | — | WO | disclosed |