⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6372816 | 0.82 | CYP1A2 (0.30) | — | |
| SCHEMBL531924 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28417197 | 0.78 | — | — | |
| Hydrochloric Acid SCHEMBL28375754 | 0.76 | CYP1A2 (0.34) | — | |
| SCHEMBL34281 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL2997324 | 0.72 | — | — | |
| SCHEMBL19915260 | 0.70 | CYP1A2 (0.31) | — | |
| SCHEMBL3778584 | 0.70 | — | — | |
| SCHEMBL8159853 | 0.68 | CYP1A2 (0.30) | — | |
| SCHEMBL6446030 | 0.68 | CYP1A2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318856-B2 | Nucleic acid delivery system comprising conjugates of PEI and hyaluronic acid | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2012-11-27 | — | — | US | disclosed |
| US-20100144035-A1 | Delivery system for nucleic acids using cationic polymer conjugates | POSTECH ACADEMY-INDUSTRY FOUNDATION | 2010-06-10 | — | — | US | disclosed |
| WO-2009020270-A1 | DELIVERY SYSTEM FOR NUCLEIC ACIDS USING CATIONIC POLYMER CONJUGATES | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2009-02-12 | — | — | WO | disclosed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0458549-A1 | N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |