Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.48 |
| ▸ | PRCP | P42785 | 10/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392181 | 1.00 | HPGDS (0.48) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL691386 | 0.97 | HPGDS (0.48) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL691385 | 0.97 | HPGDS (0.48) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL690876 | 0.91 | HPGDS (0.44) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL933671 | 0.89 | HPGDS (0.39) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL932640 | 0.89 | HPGDS (0.40) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL12158987 | 0.88 | PRCP (0.42) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL19334198 | 0.88 | HPGDS (0.48) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL13293928 | 0.88 | PRCP (0.42) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 | |
| SCHEMBL933583 | 0.88 | PRCP (0.39) | HPGDSPRCPCYP3A4CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528232-A | Hepatitis C virus inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2009-09-09 | — | — | CN | claimed |
| CN-101528232-B | Hepatitis c virus inhibitors | BRISTOL MYERS SQUIBB CO | 2014-11-12 | — | — | CN | disclosed |
| EP-2242752-A1 | IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009102325-A1 | IMIDAZOLYL BIPHENYL IMIDAZOLES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |
| EP-2049522-A2 | HEPATITIS C VIRUS INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008021927-A2 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-02-21 | — | — | WO | disclosed |