Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.64 |
| ▸ | FBP1 | P09467 | 2/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433015 | 0.90 | EGFR (0.62) | EGFRERBB2KDREPHA2 | |
| SCHEMBL3391872 | 0.90 | EGFR (0.73) | EGFRERBB2FBP1KDRKDM4E | |
| SCHEMBL3389265 | 0.89 | EGFR (0.60) | EGFRERBB2MAPK14 | |
| SCHEMBL3395371 | 0.89 | EGFR (0.65) | EGFRERBB2MAPK13MAPK12MAPK11 | |
| SCHEMBL3390805 | 0.89 | EGFR (0.76) | EGFRERBB2 | |
| SCHEMBL3431548 | 0.88 | EGFR (0.66) | EGFRERBB2FBP1KDRGAK | |
| SCHEMBL3395092 | 0.88 | EGFR (0.74) | EGFRERBB2KDREPHA2 | |
| SCHEMBL3390863 | 0.87 | ERBB2 (0.74) | EGFRERBB2KDREPHA2 | |
| SCHEMBL3395689 | 0.87 | EGFR (0.61) | EGFRERBB2KDREPHA2 | |
| SCHEMBL3391878 | 0.87 | EGFR (0.63) | EGFRERBB2KDREPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167492-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | Hanmi Pharm. Co., Ltd. (KR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008150118-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | HANMI PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | disclosed |