SCHEMBL3392894

SCHEMBL3392894

CCCCOC(=O)N1CCC(O)C(N)C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.49
LMNA P02545 2/20 0.49
POLB P06746 1/20 0.49
GBA2 Q9HCG7 1/20 0.42
GAA P10253 1/20 0.41
GNAI3 P08754 1/20 0.38
GNAO1 P09471 1/20 0.38
GNAI1 P63096 1/20 0.38
NOS3 P29474 1/20 0.37
NOS2 P35228 1/20 0.37
HPGD P15428 1/20 0.36
ALDH1A1 P00352 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
CHRM1 P11229 2/20 0.36
CHRM2 P08172 1/20 0.36
HRH2 P25021 1/20 0.36
HRH1 P35367 1/20 0.36
PDE4B Q07343 1/20 0.35
ATM Q13315 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29838376 1.00 SMN1; SMN2 (0.49) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL1542778 0.87 LMNA (0.49) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL9721655 0.86 GAA (0.54) SMN1; SMN2POLBGAANOS3NOS2
SCHEMBL9721669 0.86 GAA (0.54) SMN1; SMN2POLBGAANOS3NOS2
SCHEMBL9721662 0.86 GAA (0.54) SMN1; SMN2POLBGAANOS3NOS2
SCHEMBL29838479 0.86 SMN1; SMN2 (0.49) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL16131560 0.84 POLB (0.50) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL2778567 0.84 SMN1; SMN2 (0.53) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL323088 0.84 SMN1; SMN2 (0.53) SMN1; SMN2LMNAPOLBGBA2GAA
SCHEMBL30816157 0.83 LMNA (0.54) SMN1; SMN2LMNAPOLBGBA2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1863812-B1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG LIFE SCIENCES LTD (KR) 2010-07-14 EP disclosed
EP-1863812-A4 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG LIFE SCIENCES LTD (KR) 2009-06-24 EP disclosed
EP-1863812-A1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG Life Sciences Ltd. (KR) 2007-12-12 EP disclosed
WO-2006104356-A1 DIPEPTIDYL PEPTIDASE-IV INHIBITING COMPOUNDS, METHODS OF PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE AGENT LG LIFE SCIENCES, LTD. (KR) 2006-10-05 WO disclosed