Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | BAD | Q92934 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1047916 | 0.79 | ZAP70 (0.65) | SYKAIMP2EPHX2SRCEGFR | |
| SCHEMBL3394570 | 0.76 | ZAP70 (0.55) | KDM4ETSHR | |
| SCHEMBL3360206 | 0.74 | ZAP70 (0.42) | SYKBTK | |
| SCHEMBL12929344 | 0.71 | SYK (0.49) | SYKAIMP2SRCEGFRBTK | |
| SCHEMBL14578174 | 0.71 | EPHX2 (0.61) | SYKEPHX2SRCKDM4EALDH1A1 | |
| SCHEMBL488950 | 0.69 | MET (0.57) | SYKAIMP2EPHX2SRCEGFR | |
| SCHEMBL3459344 | 0.68 | SRC (0.59) | SYKAIMP2EPHX2SRCEGFR | |
| SCHEMBL3360194 | 0.68 | SRC (0.46) | SYKAIMP2EPHX2SRCEGFR | |
| SCHEMBL4209736 | 0.67 | EPHX2 (0.54) | SYKAIMP2EPHX2SRCEGFR | |
| SCHEMBL3359769 | 0.67 | SYK (0.43) | SYKAIMP2EPHX2SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |