Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.51 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | CLK1 | P49759 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17821837 | 0.79 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2CLK1PIK3CA | |
| SCHEMBL17821835 | 0.79 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2CLK1PIK3CA | |
| SCHEMBL14421965 | 0.77 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1PIK3CA | |
| SCHEMBL30640621 | 0.76 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2PRKCI | |
| SCHEMBL8187712 | 0.76 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2PRKCI | |
| SCHEMBL155111 | 0.76 | MAPT (0.53) | DYRK1ADYRK1BDYRK2GPR183PRKCI | |
| SCHEMBL29584634 | 0.76 | MAPT (0.53) | DYRK1ADYRK1BDYRK2GPR183PRKCI | |
| SCHEMBL15965547 | 0.76 | DYRK1A (0.54) | DYRK1ADYRK1BDYRK2CLK1PIK3CA | |
| SCHEMBL11981321 | 0.76 | CYP3A4 (0.56) | DYRK1ADYRK1BDYRK2CLK1ATM | |
| SCHEMBL7839082 | 0.75 | MAPT (0.52) | DYRK1ADYRK1BDYRK2GPR183PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |